Abstract
A three-dimensional porous scaffold is one of the standard and evocative approaches to create a favorable biomechanical environment in tissue engineering for tissue regeneration and repair. The architectural design parameters (e.g., pore-shape, size, distribution and interconnectivity; permeability; specific surface area; etc.) of the porous model have significant influence on their mechano-biological behavior. Along with this, interstitial fluid flow dynamics within the porous scaffold also regulate cell behavior. Therefore, von Mises stress, deformation, wall shear stress, and permeability across the model have been investigated. In this work, a multiscale approach has been applied to explore the various mechanical stimuli that control the cell mechanobiology within a scaffold and compare it to the natural bone with different porosity to identify which architectural design of the scaffold is close to the bone.
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