Abstract
Patients with resistant hypertension are at increased risk for cardiovascular events. Mean platelet volume (MPV) is an accepted biomarker of platelet activation and considered as a risk factor for cardiovascular disease. The aim of this study was to determine whether MPV levels are higher in resistant hypertensive (RHTN) patients than in controlled hypertensive (CHTN) patients and healthy normotensive controls. 279 consecutive patients were included in this study. Patients were divided into three groups: Resistant hypertension patient group [n=78; mean age 56.8±9.8; 42 males (53.8%)]; controlled hypertension patient group [n=121; mean age 54.1±9.6; 49 males (40.5%)]; and normotensive control group [n=80; mean age 49.8±8.5; 34 males (42.5%)]. Physical examination, laboratory work-up, and 24-hour ambulatory blood pressure measurement (ABPM) were performed in all participants. The mean platelet volume levels were significantly higher in RHTN group than in the CHTN and normotensive groups (p<0.001). In correlation analysis office systolic and diastolic blood pressure was positively correlated with MPV. Our study demonstrated that MPV, as an important indicator of platelet activation, was statistically higher in RHTN patients than in CHTN and in normotensive subjects. Elevated MPV levels may help to determine a high risk group for atherosclerosis in RHTN patients.
Highlights
Resistant hypertension (RHTN) is an increasingly common clinical problem that studies have suggested is almost always heterogeneous in terms of etiology, risk factors and comorbidities [1]
The mean platelet volume levels were significantly higher in RHTN group than in the controlled hypertensive (CHTN) and normotensive groups (p
In correlation analysis office systolic and diastolic blood pressure was positively correlated with Mean platelet volume (MPV)
Summary
Resistant hypertension (RHTN) is an increasingly common clinical problem that studies have suggested is almost always heterogeneous in terms of etiology, risk factors and comorbidities [1]. Previous studies have reported that increased platelet activity is associated with cardiovascular morbidity and mortality [5]. Mean platelet volume (MPV) is a marker of platelet size and activation, and its increased level reflects active large platelets. Some clinical studies have shown that active large platelets contain denser granules, which are metabolically and enzymatically more active than small ones and have a higher thrombotic potential [6]. Increased MPV has been found to be related with mortality after following acute myocardial infarction and restenosis [7], and this finding has been reported in hypertension background [8]. We aimed to determine whether MPV levels were higher in RHTN patients than in CHNT and healthy normotensive subjects
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