Abstract
Background Chronic Obstructive Pulmonary Disease (COPD) is fourth leading cause of death worldover. It has been defined as a state characterized by airflow obstruction due to inflammatory reaction. Various innate and adaptive immune system molecules are involved in pathogenesis of COPD. Mannose-binding lectin (MBL) is a Ca dependent collagenous lectin which intervene immune response by inhibiting pathogen activity. Point mutations, in codon 54 and 57 of exon 1 of the MBL2 have been reported to affect the serum levels of MBL. Aim of the present study was to investigate the association of MBL2 gene polymorphism with severity and susceptibility towards COPD.
Highlights
Chronic Obstructive Pulmonary Disease (COPD) is fourth leading cause of death worldover
Various innate and adaptive immune system molecules are involved in pathogenesis of COPD
Aim of the present study was to investigate the association of MBL2 gene polymorphism with severity and susceptibility towards COPD
Summary
Assessment of MBL2 gene polymorphism and lipid peroxidation in Chronic Obstructive Pulmonary Disease (COPD). From International Conference on Human Genetics and 39th Annual Meeting of the Indian Society of Human Genetics (ISHG) Ahmadabad, India. From International Conference on Human Genetics and 39th Annual Meeting of the Indian Society of Human Genetics (ISHG) Ahmadabad, India. 23-25 January 2013
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