ASSESSMENT OF LOSS OF RESPONSE TO INFLIXIMAB THERAPY IN INFLAMMATORY BOWEL DISEASES USING ANTIBODIES TO INFLIXIMAB AND TROUGH LEVELS

Abstract

Event Abstract Back to Event ASSESSMENT OF LOSS OF RESPONSE TO INFLIXIMAB THERAPY IN INFLAMMATORY BOWEL DISEASES USING ANTIBODIES TO INFLIXIMAB AND TROUGH LEVELS Luisa Guidi1*, Gianluca Andrisani1, Manuela Marzo1, Alfredo Papa1, Carla Felice1, Daniela Pugliese1, Silvia Canestri1, Barbara Tolusso1, Elisa Gremese1 and Alessandro Armuzzi1 1 Università Cattolica del Sacro Cuore, Italy Currently the management of inflammatory bowel disease (IBD) patients on infliximab therapy who lose response is mostly empirical: an increase of dose up to double or a decrease of treatment intervals is the common clinical practice, with a consequent increase of drug use and high costs. Measuring trough levels (TL) and antibodies to infliximab (ATI) may be of great benefit in optimizing therapy. We aimed to evaluate the relationship of TL and ATI assay with loss of response and infusion reactions in an Italian IBD unit. Methods: Sera were obtained from 82 IBD patients on infliximab maintenance therapy from at least 6 months. Patients were classified as being or not in clinical response. The occurrence of acute reactions to infliximab infusions was recorded. ATI and TL were measured by a commercial ELISA (Immundiagnostik AG, Bernsheim, Germany). Results: ATI were detected in 18 patients (22%), 50% of which were in clinical response as compared to 80% of patients without detectable serum ATI levels (p=0.0271 by χ2 test). 5/18 (28%) of ATI positive patients had infusion reactions as compared to 2/64 (3%) ATI negative (p=0.0047 by χ2 test). 60/82 patients had infliximab TL >0,1 µg/ml and 80% of them were in clinical response, as compared with 54% of patients with TL lower than 0,1 ug/ml (p=0.0043 by χ2 test). Median TL were not significantly different among clinical responders and non-responders. Conclusion: The combination of ATI and infliximab TL assay could help in managing loss of clinical response in IBD. Keywords: Inflammatory Bowel Diseases, infliximab, anti drug antibodies, Crohn's disease, ulcerative colitis Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Guidi L, Andrisani G, Marzo M, Papa A, Felice C, Pugliese D, Canestri S, Tolusso B, Gremese E and Armuzzi A (2013). ASSESSMENT OF LOSS OF RESPONSE TO INFLIXIMAB THERAPY IN INFLAMMATORY BOWEL DISEASES USING ANTIBODIES TO INFLIXIMAB AND TROUGH LEVELS. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00736 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Luisa Guidi, Università Cattolica del Sacro Cuore, Roma, Italy, lguidi@rm.unicatt.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Luisa Guidi Gianluca Andrisani Manuela Marzo Alfredo Papa Carla Felice Daniela Pugliese Silvia Canestri Barbara Tolusso Elisa Gremese Alessandro Armuzzi Google Luisa Guidi Gianluca Andrisani Manuela Marzo Alfredo Papa Carla Felice Daniela Pugliese Silvia Canestri Barbara Tolusso Elisa Gremese Alessandro Armuzzi Google Scholar Luisa Guidi Gianluca Andrisani Manuela Marzo Alfredo Papa Carla Felice Daniela Pugliese Silvia Canestri Barbara Tolusso Elisa Gremese Alessandro Armuzzi PubMed Luisa Guidi Gianluca Andrisani Manuela Marzo Alfredo Papa Carla Felice Daniela Pugliese Silvia Canestri Barbara Tolusso Elisa Gremese Alessandro Armuzzi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.