Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Abstract

Objective:
 Vitamin-D status is very important for optimal function of human body
 especially cardiovascular system. The aim of this study was to investigate the
 long term prognostic value of admission vitamin D level in acute ST-segment
 elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary
 intervention (PPCI). 
 
 Methods:
 One hundred fifty seven consecutive patients, who were admitted to a training
 and research hospital with a diagnosis of STEMI and underwent PPCI, were
 recruited in this prospective study. The study patients were divided into 2
 groups according to their vitamin-D levels as follows: High vitamin-D group
 (n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease
 (CAD) was assessed with calculation of the SYNTAX score. 
 
 Results:
 There were significant negative correlations between Vitamin-D level and SYNTAX
 score, serum glucose, and gender, but a positive correlation with hemoglobin
 level. Cardiovascular mortality was found to be significantly higher in the low
 vitamin-D group as compared to the high group (p<0.001). In multivariate
 analysis, low vitamin-D level was found as a significant independent predictor
 of long term cardiovascular mortality after adjusting for other risk factors. 
 
 Conclusion:
 We demonstrated that low admission vitamin-D is related to severity of CAD.
 Vitamin-D deficiency is an independent predictor for long term cardiovascular
 mortality in acute STEMI undergoing PPCI.