Abstract
：Objective To explore thevalue of two-dimensional strain echocardiography for quantitative assessing the change ofregional left ventricular myocardial function in rats following acute myocardialinfarction. Methods Sixty Wistar rats were randomly divided into two groups. The studygroup consisted of 50 rats with occlusion of LAD for 30-45 minutes and the sham-operatedgroup consisted of 10 rats without occlusion of LAD. Echocardiography were performedbefore operation, which was defined as baseline, and 1 week, 4 weeks and 8 weeks afteroperation. Left ventricular internal diameter at diastole ( LVIDd) and systole 0. 01). Compared with baseline andsham-operated group,LVIDd,LVIDs and LVM of study group all increased significantly ( P<0. 05) in 4 weeks and 8 weeks after operation,and FS and EF reduced significantly ( P<0. 05). Two-dimensional strain obtained in interobserver and intraobserver both showedhigh agreement. Conclusions Two-dimensional strain echocardiography can assess regionalfunction of myocardium with different perfusion in rats following acute myocardialinfarction, and provides a sensitive and reliable method to follow up the process of leftventricular remodeling after myocardial infarction.
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