Abstract
Methods We performed a nested case-control analysis with 1:2 matching for 39 cases of paroxysmal AF (n=28, in sinus rhythm during cardiac magnetic resonance (CMR)) and HF (n=14, AF+HF; n=3) and 78 controls with similar demographic and clinical characteristics at the baseline (Table 1). LA circumferential (short axis) and longitudinal strain rate (horizontal long axis) were measured using Multi-modality Tissue Tracking (Toshiba, Japan) from short and long-axis cine CMR images. Circumferential LA systolic dyssynchrony among 18 LA segments (6 segments x 3 slices) was evaluated as; Standard Deviation (SD) of time to pre atrial contraction Strain rate (PreA Sr) and Peak systolic strain rate (Peak Sra) (Figure 1). Similarly, longitudinal LA dyssynchrony parameters (among 6 segments) were: SD-Time to pre-atrial contraction strain rate (PreA Sr) and SD-Time to peak systolic strain rate (PeakSra). Wilcoxon-rank sum test (non-parametric) or two sample t-test (parametric) were used for comparison between the groups.
Highlights
Left atrial (LA) remodeling in response to cardiovascular and hemodynamic stress may precede atrial fibrillation (AF) and heart failure (HF)
We hypothesized that LA systolic synchronous contraction as a functional measure of LA remodeling is deranged in patients with paroxysmal AF and HF
In participants during MESA exam 5, systolic circumferential dyssynchrony (SDTP-PreA Src, msec) was significantly higher in the cases compared to controls (45.06 vs. 28.73, p
Summary
Assessment of left atrial systolic dyssynchrony in paroxysmal atrial fibrillation and heart failure using cardiac magnetic resonance imaging: MESA study. Luisa A Ciuffo1,2*, Ravi Sharma, Mohammadali Habibi, Bharath Ambale Venkatesh, Boaz D Rosen, Masamichi Imai, Steven Shea, Robyn McClelland, Colin O Wu3, Susan R Heckbert, David Bluemke, Joao A Lima
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