Abstract
BackgroundCardiac positron emission tomography/magnetic resonance imaging (PET/MRI) can assess various cardiovascular diseases. In this study, we intra-individually compared right (RV) and left ventricular (LV) parameters obtained from dual-tracer PET/MRI scan. MethodsIn 22 patients with coronary heart disease (69 ± 9 years) dynamic [13N]NH3 (NH3) and [18F]FDG (FDG) PET scans were acquired. The first 2 minutes were used to calculate LV and RV first-pass ejection fraction (FPEF). Additionally, LV end-systolic (LVESV) and end-diastolic (LVEDV) volume and ejection fraction (LVEF) were calculated from the early (EP) and late-myocardial phases (LP). MRI served as a reference. ResultsRVFPEF and LVFPEF from FDG and NH3 as well as RVEF and LVEF from MRI were (28 ± 11%, 32 ± 15%), (32 ± 11%, 41 ± 14%) and (42 ± 16%, 45 ± 19%), respectively. LVESV, LVEDV and LVEF from EP FDG and NH3 in 8 and 16 gates were [71 (15 to 213 mL), 98 (16 to 241 mL), 32 ± 17%] and [50 (17 to 206 mL), 93 (13 to 219 mL), 36 ± 17%] as well as [60 (19 to 360 mL), 109 (56 to 384 mL), 41 ± 22%] and [54 (16 to 371 mL), 116 (57 to 431 mL), 46 ± 24%], respectively. Moreover, LVESV, LVEDV and LVEF acquired from LP FDG and NH3 were (85 ± 63 mL, 138 ± 63 mL, 47 ± 19%) and (79 ± 56 mL, 137 ± 63 mL, 47 ± 20%), respectively. The LVESV, LVEDV from MRI were 93 ± 66 mL and 153 ± 71 mL, respectively. Significant correlations were observed for RVFPEF and LVFPEF between FDG and MRI (R = .51, P = .01; R = .64, P = .001), respectively. LVESV, LVEDV, and LVEF revealed moderate to strong correlations to MRI when they acquired from EP FDG and NH3 in 16 gates (all R > .7, P = .000). Similarly, all LV parameters from LP FDG and NH3 correlated good to strongly positive with MRI (all R > .7, and P < .001), except EDV from NH3 weakly correlated to EDV of MRI (R = .54, P < .05). Generally, Bland-Altman plots showed good agreements between PET and MRI. ConclusionsDeriving LV and RV functional values from various phases of dynamic NH3 and FDG PET is feasible. These results could open a new perspective for further clinical applications of the PET examinations.
Highlights
Cardiovascular diseases, especially coronary heart disease (CHD), remain the leading cause of death worldwide.[1]
left ventricular parameters such as end-systolic volume (LVESV), LV end-systolic (LVESV) and enddiastolic (LVEDV) and LVEF acquired from late-myocardial phases (LP) FDG and NH3 were (85 ± 63 mL, 138 ± 63 mL, 47 ± 19%) and (79 ± 56 mL, 137 ± 63 mL, 47 ± 20%), respectively
Deriving left ventricular (LV) and RV functional values from various phases of dynamic NH3 and FDG positron emission tomography (PET) is feasible. These results could open a new perspective for further clinical applications of the PET examinations. (J Nucl Cardiol 2020)
Summary
Cardiovascular diseases, especially coronary heart disease (CHD), remain the leading cause of death worldwide.[1] Besides an optimal physical examination, various non-invasive methods such as electrocardiography, echocardiography, computed tomography angiography, cardiac magnetic resonance imaging (CMR), and cardiac positron emission tomography (PET) using different radioactive tracers are nowadays available helping accurate detection and precise determination of the underlying cardiac illnesses. The recent development of an integrated PET/MRI imaging system could further facilitate the early diagnosis of plenty cardiovascular conditions, which might improve therapy management and reduce mortality among affected patients.[2] Due to its excellent spatial and temporal resolution and its ability to characterize myocardial composition, CMR represents a well-established imaging method in ischemic heart disease and cardiomyopathies. Cardiac positron emission tomography/magnetic resonance imaging (PET/ MRI) can assess various cardiovascular diseases. We intra-individually compared right (RV) and left ventricular (LV) parameters obtained from dual-tracer PET/MRI scan
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