Abstract
Assessment of l-ascorbic acid requirement for prolonged survival in ODS (genotype: od/od) rats and their susceptibility to urinary bladder carcinogenesis by N-butyl- N-(4-hydroxybutyl)-nitrosamine (BBN) were examined. In ODS rats without l-ascorbic acid synthesizing ability, the 50 ppm dietary total ascorbic acid (TAA) was insufficient to survive for 4 weeks, the 250 ppm dietary TAA was sufficient to survive for 36 weeks. In examination of BBN treatment, ODS rats - although showing a lower availability of TAA than the heterozygotes (+/od) and normal ( + + ) rats with l-ascorbic acid synthesizing ability-were equally susceptible to bladder carcinogenesis.
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