Abstract
Background: Anemia is one of the complications of chronic kidney disease (CKD) which necessitates multiple blood transfusions. These multiple transfusions are usually accompanied by Iron over load. The current study aimed to assess the Iron profile in Sudanese patients with chronic renal failure received regular blood transfused. Materials and Methods: A descriptive analytical case control study was performed in Alturki Teaching Hospital, Khartoum, Sudan. A total of 90 Sudanese were enrolled in this study (30 CKD patients under hemodialysis and undergo multiple blood transfusion, 30 CKD patients under hemodialysis but not blood transfusion and 30 healthy controls, 51 (57%) were male and 39 (43%) were females, their age ranged between 28 to 75 years. Iron profile (serum iron, serum ferritin and total iron binding capacity (TIBC)) were measured using full automated Chemical analyzer Mindray BS 200 (China). Data were analyzed by using statistical package for social sciences (SPSS) verssion16. Results: The present study showed that serum iron and serum ferritin of those under hemodialysis and received regular blood transfusion patient were significantly higher compared to those under hemodialysis and did not received regular blood transfusion patients (P value 0.000 and 0.01) respectively. Conclusion: Patients with chronic renal failure and under hemodialysis and receive regular and multiple transfusions are prone to iron overload.
Highlights
Anemia commonly occurs in people with chronic kidney disease (CKD)—the permanent, partial losses of kid-How to cite this paper: Alla, M.B.A.A., Adam, K.M. and Mohammed, N.E.A. (2016) Assessment of Iron Profile among Transfused Dependent Chronic Renal Failure Sudanese Patients
The present study revealed that the iron profile were statistically significant different in patient with chronic renal failure received blood transfused compared with those non blood transfused (p value 0.00, 0.01 and 0.00) respectively
EschbacH et al, who studied 166 transfused hemodialysis patients and reported that the iron status was increase, second study done by Canavese C, Bergamo D, Ciccone G, et al in 2004 who was estimate the iron profile in 40 transfused hemodialysis patients and reported that 30% of the patients were normal and 70% iron were over load
Summary
Anemia commonly occurs in people with chronic kidney disease (CKD)—the permanent, partial losses of kid-How to cite this paper: Alla, M.B.A.A., Adam, K.M. and Mohammed, N.E.A. (2016) Assessment of Iron Profile among Transfused Dependent Chronic Renal Failure Sudanese Patients. (2016) Assessment of Iron Profile among Transfused Dependent Chronic Renal Failure Sudanese Patients. Anemia is one of the complications of chronic kidney disease (CKD) which necessitates multiple blood transfusions. These multiple transfusions are usually accompanied by Iron over load. The current study aimed to assess the Iron profile in Sudanese patients with chronic renal failure received regular blood transfused. A total of 90 Sudanese were enrolled in this study (30 CKD patients under hemodialysis and undergo multiple blood transfusion, 30 CKD patients under hemodialysis but not blood transfusion and 30 healthy controls, 51 (57%) were male and 39 (43%) were females, their age ranged between 28 to 75 years. Conclusion: Patients with chronic renal failure and under hemodialysis and receive regular and multiple transfusions are prone to iron overload
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