Abstract
Introduction: Elevated levels of interleukin (IL)-6 and IL-10 are promising surrogate biomarkers implicated in outcome and survival in HNSCC. Investigation of interleukins in a translational model of HNSCC may elucidate their role. Feline oral squamous cell carcinoma (FOSCC) is an excellent model of advanced stage HNSCC and represents a novel, relevant, and underutilized resource in translational cancer research. Molecular similarities include p53 mutations, COX-2 and EGFR expression, tobacco smoke exposure, and a possible role of papillomavirus. The aim of this study was to characterize serum levels of IL-6 and IL-10 in naturally occurring FOSCC.
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