ASSESSMENT OF INSULIN RESISTANCE IN NONALCOHOLIC FATTY LIVER DISEASE IN NON-DIABETIC PATIENTS

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of liver damage ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). The ectopic accumulation of fat in the liver has been strongly associated with insulin resistance. To Aim of the study: explore the proportion of insulin resistance in non-diabetic NAFLD patients compared to normal healthy populations using HOMA-IR model. Materials and Methods: This was a hospital based case control study carried out on 100 patients diagnosed with NAFLD by ultrasound. Fasting Insulin estimation was done by Insulin IRMA (IMMUNORADIOMETRIC ASSAY) Kit. P Results: atients with NAFLD had a higher prevalence (33%) of metabolic syndrome than the controls (15%) with an Odds Ratio of 2.791. Insulin resistance in non-diabetic NAFLD patients was higher (36%) than the control populations (11%) (p value was <0.001). This study has shown that insuli Conclusion: n resistance has a positive association with NAFLD