Assessment of Inflammatory Markers in Hemolytic Crisis with Special Reference to Sickle Cell Anemia

Abstract

As a global health problem sickle cell anemia affects many world populations. It is an autosomal recessive disease, commonly found in tropical countries. It is the most common single genetic mutation in human and abundantly present in large part of the world. The present study was done in the Department of Biochemistry, Chhattisgarh Institute of Medical Sciences, Bilaspur. The work comprised of two different groups consisting 50 sickle cell patients with hyperhemolytic crisis, including 50 age and sex matched control subject. In the present study namely, Homosysteine, IL-6, TNF-a, and CRP as an inflammatory markers measured in normal and sickle cell disease patients. We found significantly increased mean level of all three parameters (IL-6 Group I V/s Group II p <0.001, TNF-α Group I V/s Group II p < 0.001, CRP Group I V/s Group II p <0.001). when compared to control and subject group.