Abstract
Inflammasome is a multiprotein oligomer complex which is the precursor procaspase-1 and is a component of the innate immune system so that this study aimed to determine the serum levels of interleukin-1? and 18 in patients with T2D and simple obesity in an attempt to clarify the role of inflammasome in these disorders.Twenty five known cases of T2D, twenty four patients with simple obesity and twenty healthy subjects were randomly recruited from AL-Kindy Teaching Hospital in Baghdad to enroll in this study. All the data about the demographic characteristics and anthropometric measurements were determined in all patients, also the C-reactive protein and serum interleukin (IL)-1? and IL-18 levels were obtained from each patient. The results showed that patients who had positive C-reactive protein (? 6 mg/L) had significant high level of serum 1? and IL-18 levels. Concomitant significant increase in serum levels of IL-1? and IL-18 was observed only in 8% (2 out of 25) of T2D. It concludes that the activity of inflammasome is observed in low percent of T2D and this activity does not related to the obesity.
Highlights
Inflammasome is a multiprotein oligomer complex that comprises an intracellular sensor typically a Nodlike receptor which is the precursor procaspase-1 and the apoptosisassociated speck-like protein containing caspase activation and recruitment domain Inflammasome is considered a component of innate immune system
Serum level of IL1β was significantly elevated in 12.5% (3 out of cases) of simple obesity patients compared with 32% (8 out of cases) of type 2 diabetes mellitus (T2D)
The results of this study demonstrate that inflammasome is involved in pathogenesis of out of twenty five (8%) T2D patients and the significant high level of IL-1β concentration in T2D and to less extent in simple obesity indicated the role of these biomarkers in their pathogenesis
Summary
Inflammasome is a multiprotein oligomer complex that comprises an intracellular sensor typically a Nodlike receptor which is the precursor procaspase-1 and the apoptosisassociated speck-like protein containing caspase activation and recruitment domain Inflammasome is considered a component of innate immune system. It is expressed in many cells including myeloid cells.As a result of inflammasome activation the mature IL-1β and IL-18 will release from cells [1]. This study was aimed to assess the activity of inflammasome in type 2 Diabetes and simple obesity in which low grade of inflammation played a role in their pathogenesis by determining the serum level of IL-1β and IL-18
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