Abstract
On the investigation of the in-vitro cytotoxicity of composite materials containing poly-L-lactic acid (PLLA) and β-tricalcium phosphate (β-TCP), the second part of the in-vivo cytotoxicity was investigated by acute systemic toxicity test, haemolytic test, skin sensitisation test, micronucleus test and subcutaneous implant test. The results indicated that there was no toxicosis or death cases observed in acute systemic toxicity test. The PLLA/β-TCP composite showed no genetic toxicity and sensitising response, and the haemolytic index was 0.39%. The histological observation of the tissue response showed that the inflammatory response to PLLA/β-TCP continued to decrease, which indicated the composite materials had a good biocompatibility. Therefore, PLLA/β-TCP composite materials can be a promising candidate of biomedical materials for bone tissue engineering.
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