Abstract
The current study was carried out to assess the immunomodulatory activity of Ethanolic extract Crataeva nurvula bark (EECNB) using in vitro methods. In vitro immune modulatory activity was investigated by cellular lysosomal enzyme assay and phagocytosis evaluation. The release of cellular lysosomal enzyme was found to be significant (p<0.05) at 200 μg/ml (Stimulation Index = 1.982) and 100 μg/ml (S.I= 1.564) of EECN with respect to control PHA (Stimulation Index =1.00) maximum phagocytic activity of EECNB was evident at 500g/ml and With gradual increase in the dilutions of the plant extract there was a corresponding decrease in phagocytic activity. The present has demonstrated the immunomodulatory potential of EECNB (as it has good stimulation index and maximum phagocytic activity) based on the results of lysosomal and phagocytosis assay. Further studies are needed to support its immonumodulatory activity.
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