Abstract
The aim of the study was to assess the antifungal activity of preparation „fin Candimis” (oregano essential oil) against yeast-like strains belonging to the genus <em>Candida</em>. During the investigation, there were used up nine <em>Candida albicans</em> strains and ten C. glabrata strains isolated from different clinical material, along with one <em>C. albicans</em> demonstration strain ATCC 90028. The oregano essential oil, utilized in the study, was obtained from fresh leaves of <em>Origanum vulgare</em> L. and bore a trade name „fin Candimis”. According to data yielded by its manufacturer, concentration of pure oregano essential oil in preparation „fin Candimis” totals up to 210 mg/ml. The susceptibility of the <em>Candida</em> strains to preparation „fin Candimis” was assessed by means of the disc-diffusion method, upon the Sabouraud solid medium (after a 24-hour incubation of the cultures at temperature of 37 degrees centigrade); the oregano essential oil had been diluted in 1 ml of DMSO, according to the geometrical progression. A measure of the antifungal activity of preparation „fin Candimis” was the minimal inhibitory concentration (MIC), in terms of the fungus growth. Preparation „fin Candimis” is capable of being applied in the prevention and treatment of candidiasis – alone, or as a natural adjunctive agent. The <em>C. albicans</em> strains are more susceptible to preparation „fin Candimis” in comparison to the <em>C. glabrata</em> ones.
Highlights
According to epidemiological data spreading over the past two decades, there has been observed in the world a significant increase in the number of infections caused by fungi belonging to the genus Candida, referring to patients admitted to intensive care units, undergoing immunosuppression or taking broad-spectrum antibiotics, and after having received a graft (Rex 1995; E g g i m a n n, G a b r in o a n d P i t ter 2003; Krutkiewicz 2010).The epidemiological situation impels scientists to search for new therapeutic agents – among the others, natural and vegetal ones – which bear the stamp of high effectiveness and low toxicity
The antifungal activity of preparation „fin Candimis” was assessed in vitro by means of the disc-diffusion method against 19 fungi strains belonging to the genus Candida, which had been isolated from aspirate of the upper airways (18 strains) and from urine
From amongst 19 Candida strains, nine strains belonged to the species C. albicans, and ten did to the species C. glabrata
Summary
The epidemiological situation impels scientists to search for new therapeutic agents – among the others, natural and vegetal ones – which bear the stamp of high effectiveness and low toxicity. These compounds could be useful in the field of antifungal prophylaxis and treatment. To this group there belong essential oils which present antifungal properties – inclusive of Origanum vulgare essential oil, popularly named oregano. Origanum vulgare has been known for its healing properties. In the Middle Ages, oregano was an ingredient of the infusion that was dispensed in order to protect from wizardries
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