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Abstract
The design and evaluation of antimicrobial activities of an isonitrosomalononitrile silver(I) salt was reported. This highly stable water-soluble silver salt shows Minimum Inhibitory Concentrations (MIC) values ranging from 0.15 to 5 µg/mL towards both sensitive and resistant Gram-positive and negative bacteria. Furthermore, this silver salt has been investigated for its ability to treat a S. aureus infected Galleria mellonella larvae animal model with promising results. Thus, our results demonstrated that 80% of the treated larvae survived after 24h with respect to 10% of the untreated ones, respectively.
Highlights
Extensive misuse of antibiotics world wide lead to the emergence of antimicrobial resistance as a major threat to healthcare [1]
This paper describes the synthesis and biological antimicrobial evaluation of a new isonitrosomalononitrile silver salt against both Gram-positive and negative bacteria and demonstrates its in vivo efficiency against a S. aureus infected G. mellonella larvae animal model
We prepared the corresponding isonitrosomalononitrile potassium salt 3 parent derivatives to compare the influence of the nature of the metal used on the potent antimicrobial activities encountered
Summary
Extensive misuse of antibiotics world wide lead to the emergence of antimicrobial resistance as a major threat to healthcare [1]. This paper describes the synthesis and biological antimicrobial evaluation of a new isonitrosomalononitrile silver salt against both Gram-positive and negative bacteria and demonstrates its in vivo efficiency against a S. aureus infected G. mellonella larvae animal model. The X-ray diffraction analysis of the synthesized powder of 3 confirmed the correlation with the determined crystal structure of isonitrosomalononitrile potassium salt 3 and the purity of the sample.
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