Assessment of Human Health Risks Associated with Heavy Metals Accumulation in the Freshwater Fish Pangasianodon hypophthalmus in Bangladesh

Md Abdullah-Hil Maruf,Mohammad Moniruzzaman,Badhan Saha,Priyanka Dey Suchi,Nusrat Jahan Punom,Md Mostavi Enan Eshik,Mohammad Shamsur Rahman

doi:10.1007/s12403-021-00387-8

Md Abdullah-Hil Maruf, Mohammad Moniruzzaman + Show 5 more

Open Access

https://doi.org/10.1007/s12403-021-00387-8

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Abstract

In this study, pangas and feed samples were analyzed to estimate the levels of metallic elements and to profile the human health risks due to consumption of contaminated fish. This investigation confirmed significant variations in heavy metal concentrations among different tissues of pangas in the order of Ni > Cu > Pb > Cd > Cr in pre-monsoon and Ni > Cd = Cu > Pb = Cr in post-monsoon. Considerably higher concentrations of Pb, Cu, and Cr were estimated in liver; and Cd and Ni were detected in muscle than in other organs (p > 0.05). Statistically significant higher amounts of Cd, Ni, and Cu were observed in pre-monsoon than in post-monsoon. Furthermore, three metal pairs showed significant association (Pb–Ni and Pb–Cu involved positively; Cd–Ni acted negatively). In pre-monsoon, Cd, Pb, Ni, and Cu concentrations of feed significantly differed than those of pangas contents, whereas only Cu varied during the post-monsoon. Regression analysis revealed the significant effect of Ni content in feed on the Cu deposition of pangas (p-value 0.027, that was < 0.05). For the assessment of potential human health risk of the studied metals, estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and carcinogenic risk (CR) indices were calculated. Studied EDI indicated that an average adult ingested a higher amount of Ni and Cu than the recommended intake limit. Nevertheless, only the higher EDI of Ni increases the value of THQ and HI than standard limit indicates adverse non-carcinogenic risk. However, lower CR of Pb confirmed no serious health hazard due to the ingestion of pangas. Factor analysis through principal component and cluster analysis suggested that higher concentrations of Pb and Ni may be regulated by the feed used, geochemical properties, or rapid industrialization in the study area. A proper monitoring for controlling the quality of fish feed with sustainable planning for industrialization could secure the booming of pangasius aquaculture in Bangladesh.

Highlights

Aquatic environment has become polluted with heavy metals day by day which acts like a global issue of scientific concern, because these metals are indestructible and most of them have toxic effects on organisms (Islam et al, 2017)
During pre-monsoon of 2017, pangas liver of Muktagacha contained the highest amount of cadmium, Cd (0.0933 mg/kg) whereas the lowest value of Cd was recorded in gill sample of Muktagacha and Trishal (0.03 mg/kg)
If we considered the individual sampling sites, no one crosses the acceptable limit of hazard index suggested by literature (Lei et al, 2015; Dadar et al, 2017) and confirmed less non-carcinogenic risk effects due to the ingestion of pangas

Summary

Introduction

Aquatic environment has become polluted with heavy metals day by day which acts like a global issue of scientific concern, because these metals are indestructible and most of them have toxic effects on organisms (Islam et al, 2017). Heavy metals contamination of aquatic ecosystems is becoming an alarming issue for public health as its potential bioaccumulation mechanism from fish to human (Le and Ngo, 2013). Acute and prolonged exposure or contact to metallic elements lead extreme toxicity, renal and hepatopancreatic dysfunction, even carcinogenicity of the brain, prostate gland, and other organs of a human being (Vannoort and Thomson, 2005; Gray et al, 2005; García-Lestón et al, 2010).

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