Abstract
Assessment of Hormone Levels in Men with Fertility Problems Attending a Tertiary Infertility Center in North Karnataka
Highlights
Spermatogenesis encompasses an intricate network of processes that occur in the seminiferous tubules and culminates in the production of the mature male gamete [1]
The release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland is elicited by gonadotropin-releasing hormone (GnRh) secreted by the hypothalamus [4]
FSH directly acts on sertoli cells to stimulate spermatogenesis and LH plays an indirect role by stimulating the production of testosterone in Leydig cells which in turn acts on sertoli and peritubular cells to produce spermatozoa [11]
Summary
Spermatogenesis encompasses an intricate network of processes that occur in the seminiferous tubules and culminates in the production of the mature male gamete [1]. The release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland is elicited by gonadotropin-releasing hormone (GnRh) secreted by the hypothalamus [4]. FSH binds to receptors in the Sertoli cells and stimulates spermatogenesis [5]. LH stimulates the production of Testosterone (T) by the Leydig cells, and in turn, acts on the Sertoli and peritubular cells of the seminiferous tubules to stimulate spermatogenesis [6]. The failure of the pituitary to secret FSH and LH will result in disruption of testicular function leading to infertility [7]. Only 2% of male infertility is due to an endocrinological cause [8], identification is important, as specific hormonal therapy is often successful
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