Abstract
Background & Aim: Simple hepatic steatosis is a benign condition, but it may cause serious liver damage as it may lead to steatohepatitis, fibrosis and cirrhosis. The Controlled Attenuation Parameter (CAP) of fibroscan assesses hepatic steatosis. The aim of this work was to assess hepatic steatosis in patients with chronic hepatitis B infection using FibroScan and to detect its relation to insulin resistance. Methods: Seventy-seven patients with chronic HBV were enrolled in this study. Body mass index, complete lipid profile, fasting insulin, HOMA-IR, pelviabdominal ultrasound and fibroscan were assessed in all patients. Results: According to the presence of significant steatosis, seventy-seven patients enrolled in this study were divided into different groups, such as group I 47 patients (61.04%) with CHB virus infection with non-significant steatosis and group II 30 patients (38.96%) with CHB infection with significant steatosis. There was a statistically significant increase in fasting insulin and HOMA-IR in group II (p-value <0.001). CAP results ranged from 100-396 db/m with no significant difference in liver stiffness measurements in two studied groups (P value= 0.886). There was a significant positive correlation between the degree of hepatic steatosis measured by fibroscan and fasting insulin blood level, HOMA-IR, serum cholesterol and LDL. At cutoff > 222 db/m steatosis measured by fibroscan had a sensitivity of 63.33% and specificity of 82.35% for the detection of insulin resistance. Conclusion: In CHB infected patients, steatosis measurement by fibroscan was a strong predictor of Insulin Resistance (IR) and vice versa.
Highlights
Hepatitis B Virus (HBV) infection is still considered a serious universal public health problem in spite of the effective HBV vaccination programs [1]
33 patients were excluded Hepatitis C virus infection, previous or ongoing alcoholism, Diabetes mellitus, patients with body mass index < 29.9, hepatic malignancy, use of medications associated with fatty liver disease within the past year
There were no statistical differences between the studied groups regarding age, sex, liver function tests, complete blood picture, prothrombin time, serum creatinine level, fasting blood sugar level, and quantitative PCR of HBV DNA, BMI, cholesterol, triglycerides, high-density lipoproteins (HDL), Low-density Lipopro-teins (LDL), and liver stiffness measured by Fibroscan (Table 1)
Summary
Hepatitis B Virus (HBV) infection is still considered a serious universal public health problem in spite of the effective HBV vaccination programs [1]. Simple hepatic steatosis is a benign condition that occurs when fat deposition in the liver exceeds 5% of the gross total weight of the liver, or more than 5% of hepatocytes containing fat deposits, but this benign condition may cause serious liver damage as it may develop into steatohepatitis, fibrosis and cirrhosis [4]. Liver biopsy is still considered as the ‘gold standard’ for diagnosing hepatic steatosis. It is associated with the risk of complications in 0.5%, and mortality in about 0.05% of the cases due to its invasive nature [5]. Simple hepatic steatosis is a benign condition, but it may cause serious liver damage as it may lead to steatohepatitis, fibrosis and cirrhosis. The aim of this work was to assess hepatic steatosis in patients with chronic hepatitis B infection using FibroScan and to detect its relation to insulin resistance
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