Abstract
Assessment of hemodialysis effect on left ventricular mechanical dyssynchrony by tissue synchronization imaging
Highlights
Cardiac disease is the major cause of premature deaths in hemodialysis (HD) patients, accounting for 43% of all-cause mortality [1,2], and the frequency of sudden cardiac death is almost 50% higher after the long dialysis interval [3]
A factor that may have a potential to contribute to the high incidence of cardiac deaths in end-stage renal disease (ESRD) patients is intra-left ventricular (LV) mechanical dyssynchrony, a disorder that markedly affects systolic performance, cardiac electrophysiology, regional myocardial perfusion and metabolism [4,5]
The objective of this study was to evaluate the possible presence of LV dyssynchrony in ESRD patients, and acute effect of hemodialysis (HD) on LV synchronicity using tissue synchronization imaging (TSI)
Summary
Cardiac disease is the major cause of premature deaths in hemodialysis (HD) patients, accounting for 43% of all-cause mortality [1,2], and the frequency of sudden cardiac death is almost 50% higher after the long dialysis interval [3]. A factor that may have a potential to contribute to the high incidence of cardiac deaths in end-stage renal disease (ESRD) patients is intra-left ventricular (LV) mechanical dyssynchrony, a disorder that markedly affects systolic performance, cardiac electrophysiology, regional myocardial perfusion and metabolism [4,5]. Abnormal loading conditions such as excessive volume overload can worsen LV mechanical dyssynchrony by intensifying imbalances in the regional stretching and shortening of myocardial fibers following abnormal stress to myocardial tissue, especially in patients with ESRD requiring chronic HD therapy [6]. The study aims to evaluate the possible presence of LV dyssynchrony in ESRD patients, and acute effect of hemodialysis (HD) on LV synchronicity using tissue synchronization imaging (TSI)
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