Assessment of Health-Related Quality of Life between People with Parkinson's Disease and Non-Parkinson's: Using Data Drawn from the '100 for Parkinson's' Smartphone-Based Prospective Study.

Xiaojing Fan,Gerben Bakker,Bruce Hellman,Rupert Coghlan,Ian Whetstone,Mathieu Janssen,Amelia Hursey,Duolao Wang,Helen Matthews

doi:10.3390/ijerph15112538

Abstract

Background: This study aims to assess the specific difference of the health-related quality of life between people with Parkinson’s and non-Parkinson’s. Methods: A total of 1710 people were drawn from a prospective study with a smartphone-based survey named ‘100 for Parkinson’s’ to assess health-related quality of life. The EQ-5D-5L descriptive system and the EQ visual analogue scale were used to measure health-related quality of life and a linear mixed model was used to analyze the difference. Results: The mean difference of EQ-5D-5L index values between people with Parkinson’s and non-Parkinson’s was 0.15 (95%CI: 0.12, 0.18) at baseline; it changed to 0.17 (95%CI: 0.14, 0.20) at the end of study. The mean difference of EQ visual analogue scale scores between them increased from 10.18 (95%CI: 7.40, 12.96) to 12.19 (95%CI: 9.41, 14.97) from baseline to the end of study. Conclusion: Data can be captured from the participants’ own smart devices and support the notion that health-related quality of life for people with Parkinson’s is lower than non-Parkinson’s. This analysis provides useful evidence for the EQ-5D instrument and is helpful for public health specialists and epidemiologists to assess the health needs of people with Parkinson’s and indirectly improve their health status.

Highlights

Parkinson’s disease (PD) is a degenerative movement disorder affecting 1–2% of the population aged over 60 years and is the second most common neurodegenerative disorder after Alzheimer’s disease [1,2]
Participants used the uMotif app to record a range of data including: daily symptoms, questionnaires (EQ-5D, PDQ-8, NMS30) diaries, medications, cognitive and motor testing games, biometric results and—for those with devices—the opportunity to connect to wearable devices (i.e., Fitbit, Pedometers, Apple watch)
A total of 1710 people aged more than 45 years old, including 1050 (61.40%) people with Parkinson’s and 660 (38.60%) non-Parkinson’s completed the EQ-5D instruments via their smartphone with a mean age of 62.62 (7.47) years old and 59.69 (7.17) years old for people with Parkinson’s and non-Parkinson’s, respectively

Summary

Introduction

Parkinson’s disease (PD) is a degenerative movement disorder affecting 1–2% of the population aged over 60 years and is the second most common neurodegenerative disorder after Alzheimer’s disease [1,2]. It is a universal disorder, with an estimated global incidence of 4.5–19 per 100,000 population per year and it is expected that the number of people with PD will double by 2030 [3]. This study aims to assess the specific difference of the health-related quality of life between people with Parkinson’s and non-Parkinson’s. Conclusion: Data can be captured from the participants’ own smart devices and support the notion that health-related quality of life for people with Parkinson’s is lower than non-Parkinson’s

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Conclusion