Assessment of Gleason Score Concordance Between Prostate Biopsy and Radical Prostatectomy

Abstract

Introduction: Prostate cancer is being diagnosed and graded by examining needle biopsies. As needle biopsies may represent the low percentage of general tumor histology, downgrading or upgrading can cause problems in radical prostatectomy (RP) specimens. Our aim in this study was to put forth the concordance between needle biopsy and RP Gleason scores. Methods: The biopsy pathology results, and post-RP pathology results of 112 patients diagnosed as prostate cancer and underwent RP were revised and the concordance of the biopsy and RP Gleason score was analyzed by kappa statistics in addition to percentages of downgrading or upgrading rates. Results: The mean age, and PSA values of the patients were 64,4 (±6,2) years, and 11,7 (±9,2) ng/mL, respectively. There was a moderate agreement between biopsy and prostatectomy gleason scores(κ=0,452) and between Gleason groups Conclusion: It is important for the urologists to be aware of the variety of Gleason score between biopsy results and prostatectomy specimens as needle biopsies represent small areas of tumors