Abstract
Keeping in view the increasing importance of botanical insecticides, the various metabolites from different plants are being investigated for insecticidal activity. Alpinia galanga, a medicinal plant belonging to family Zingiberaceae exhibits a wide range of biological activities. In the present study, purified compounds of A. galanga i.e. 1′-acetoxychavicol acetate and galangin were evaluated for their effect on detoxifying enzymes viz. esterases, acid phosphatases, alkaline phosphatses and glutathione-S-transferases as well as DNA damage of the Spodoptera litura (Fab.) larvae. DNA damaging potential of both the compounds was ascertained using comet assay. The purified compounds significantly changed the enzymatic profile of S. litura as well as induced genotoxic effects. Change in enzyme activity and damage to DNA may lead to genetic and physiological changes in insect and ultimately affect its fitness and survival.
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