Abstract
Objective:Impaired gastric accommodation is one of the main symptoms in patients with functional dyspepsia. The aim of the present study was to assess gastric accommodation in patients with functional dyspepsia using single photon emission computed tomography (SPECT) imaging.Methods:Twenty-four patients with functional dyspepsia and 50 healthy volunteers as control group were enrolled in this study. All participants were given 5 mCi 99mTc-pertechtenate intravenously, served with a low fat meal, and underwent SPECT scanning 20 minutes after the meal.Results:Based on the scintigraphic data, gastric volumes were found to be significantly increased after food ingestion in both patient and control groups. We also found that while there was no significant difference between patient and control groups in terms of fasting gastric volumes, postprandial gastric volume was significantly lower in patients as compared to healthy individuals (p<0.05).Conclusion:Measuring gastric volume by using SPECT can be a valuable method in the detection of functional dyspepsia and in differentiation of this entity from other organic disorders.
Highlights
Gastric accommodation (GA) is a vagal nerve mediated reflex, which is associated with reduction in gastric tone along with an increase in gastric volume and gastric compliance [1]
Statistical analysis of the data showed a significant difference between fasting and postprandial gastric volumes in both patient (p
In the control group, fasting gastric volume was not correlated with age and body mass index (BMI) (p>0.05), but there was a correlation between fasting volume and sex (p
Summary
Gastric accommodation (GA) is a vagal nerve mediated reflex, which is associated with reduction in gastric tone along with an increase in gastric volume and gastric compliance [1]. This reflex is a predictable response in healthy subjects that allows ingestion of food without inducing postprandial symptoms. Assessment of GA may improve our understanding of the causes of upper gastrointestinal symptoms after food intake in functional and neuropathic diseases, and their effects on the outcome of treatment. Evaluation of proximal gastric motor function is of particular importance in clinical trials, as it can be used to detect abnormalities in the stomach, which in turn may be used as an indicator of upper gastrointestinal problems [4,5,6]
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