Assessment of factors affecting caregiver burden in Alzheimer disease (AD)

Abstract

Patient group was over 60 years who did not have diabetes, malignancies, acute or chronic inflammatory diseases. Volunteers had the same properties but they did not have AD. TNF-, adiponectin, ICAM-1 and VCAM-1 levels were determined by using ELISA kits. IR was calculated with Homeostasis Model Assessment (HOMA) method. Lipid levels were determined from outpatient clinic records retrospectively. Results.– Adiponectin levels in AD group were significantly higher than control group (P = 0.035), however, mean levels of TNF-, ICAM-1, VCAM-1, and lipid parameters were not statistically different. And also HOMA levels were lower in AD group than control group, but not statistically significant (P = 0.085). Conclusion.– Numerous studies investigating the relationship between AD and cytokines have contradictory results. In the literature there are a few studies concerning adiponectin and AD. In our study, adiponectin levels in AD group were significantly higher than the control group. It is possible that adiponectin may play a critical role in the onset of AD. PS: Partially presented in Academic Geriatric Congress 2012/Turkey. Disclosure.– No significant relationships.