Abstract
Background: Psoriasis is a chronic inflammatory skin disease characterized by a prominent T-cell infiltrate, epidermal hyper proliferation and abnormal keratinocyte differentiation. The present study was conducted to assess efficacy of methotrexate and acitretin in the management of psoriasis.Materials & Methods: 72 patients diagnosed with palmoplantar psoriasis were divided into 2 groups of 36 each. Group I patients were prescribed oral methotrexate15mg/week for 3 months and group II were given oral acitretin 0.5 mg/kg daily for 3 months. Modified psoriasis area severity index (MPASI) score was assessed.Results: There were 16 males and 20 females in group I and 18 males and 18 females in group II. The mean MASI score at baseline, 1 month, 2 months and 3 months was 58.2, 38.4, 23.2 and 14.6 and 60.4, 40.2, 30.5 and 20.4 in group I and II respectively. The difference was significant (P
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Dermatology, Venereology and Leprosy Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
