Abstract
Purpose: to assess effectiveness of fludarabine-containing chemotherapy programs in treatment of oncohematological patients after relapse or in primary chemoresistance. Material and methods. Within 2006-2013, 11 patients with various oncohematologic disorders were treated using fludarabine-containing high-dose chemotherapy programs FLAG or FLAG-Ida at the Republican Research Center for Radiation Medicine and Human Ecology. Results. The best results of this pilot study were obtained in the chemotherapy program FLAG-Ida. Remission was achieved in younger patients, in contrast to the group of elderly patients with no remission. All the patients who achieved remission were female, and among the 7 patients, who did not achieve remission, more than half were men. Conclusion. Thus, on the whole the fludarabine-containing programs of chemotherapy are effective in the treatment for oncohematological pathology, but further research is needed to develop a more differentiated approach to the application of the programs to improve the effectiveness of the therapy of these diseases.
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