Assessment of Effectiveness of Clonidine and Atenolol in Providing Optimal Surgical in Nasal Surgery: A Clinical Study

Abstract

Background: Although adequate level of anaesthesia is achieved by various anaesthetic solutions, tachycardia, hypertension and other cardiovascular responses usually occur following nasal speculum insertion due to failure of gaining the adequate hemodynamic response. A reduction in the hemodynamic response to noxious stimulus has been shown by the preoperative use of clonidine (α-2 agonist) and atenolol (β-blocker) at various stages of surgery. Hence, we evaluated and compared the efficacy of oral clonidine and oral atenolol when given pre-surgically in the patients undergoing nasal surgeries. Materials & Methods: The present study was conducted in the department of ENT and surgery of the medical institution and included 120 patients who underwent rhinoplasty, septoplasty, and functional endoscopic sinus surgery. All the patients were randomly divided into two study groups. First group included patients who received oral atenolol while other group included patients who received oral clonidine before induction of anaesthesia. All the clinical and hemodynamic parameters of the patients were assessed pre-surgically and during the surgery. Post-operative assessment of the hemodynamic parameters was also done. At the end of study decoding of groups and the data compilation was done. All the results were analyzed by SPSS software. Results: The mean age of the patients in the two study groups was 28.5 and 32.5 years respectively. 70 percent of the patients in the oral atenolol group were males while in oral clonidine group, 75 percent were males. Mean duration of the surgery in oral atenolol group and oral clonidine group was 119.70 and 121.50 minutes respectively. Non-significant results were obtained while comparing the p-value in between the two study groups for various demographic parameters. Significant difference was obtained while comparing the mean value of total blood loss in between the two study groups. Significant difference was obtained while comparing the quality. Conclusion: Quality of surgical filed and amount of blood loss is comparatively less with the pre-surgical use of clonidine.