Abstract
The major impact in the clinical field is the harm posed by cancer. One most common type of cancer occurs in the skin. Though the conventionally existing modalities are successful in some cases, there is a need for new sensible methods to detect tumors at their initial stage. In accordance to these reasons and in addition to the incapability of the drugs to cross cellular barriers in skin the conventional administration methods are often compromised. To eradicate these problems the research work aims to develop the electrical analogue of skin involving layers like dermis, subcutaneous tissues, bones and muscular layers. The mathematical model has been developed to determine the electrical network of skin. The response of different skin layers are analyzed through simulation studies. It is observed that the cells present in each layer absorbs some amount of drug and let out the remaining to the neighboring layers. Further to minimize the diffusion rate of the drug a conventional controller has been incorporated and the results are analyzed by the contrast of the absorption and diffusion capacities for different layers of skin.
Highlights
Cancer is a disease at the cellular level involving heritable disorders in cellular control mechanisms
A closed loop control system based on the electrical analogue of skin has been developed for computerized drug delivery (Ezra et al 1995)
The appropriate electrical network for the biological system of skin is intended and the mathematical modeling has been determined by substituting the minimal values of the resistance and capacitance for the skin
Summary
Cancer is a disease at the cellular level involving heritable disorders in cellular control mechanisms. The skin protects us from microbes and helps to regulate the body temperature and permits the sensations of touch, heat and cold. It is the outer cover of human beings which protect us from various parameters like light, water, heat, etc. Human skins show high color variations from the darkest brown to the lightest pinkish – white hues. This color variation is the highest among any other mammalian species as the result of natural selection. Skin pigmentations in the humans are evolved to regulate the amount of ultraviolet radiation penetrating the skin and to control the biochemical effects
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