Abstract
Alexandre AB Lataliza1, Laura A Junqueira1, Cristine B Amarante2, Marcos AF Brandão1, Rafael C Dutra3* and Nádia RB Raposo1* Author Affiliations 1Research and Innovation in Health Sciences (NUPICS), Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil 2Museu Paraense Emílio Goeldi, Belém, PA, Brazil 3Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Federal University of Santa Catarina, Araranguá, SC, Brazil Received: April 21, 2021 | Published: May 11, 2021 Corresponding author: Nádia RB Raposo, Research and Innovation in Health Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil. Rafael C Dutra, Department of Health Sciences, Federal University of Santa Catarina, Araranguá, Brazil DOI: 10.26717/BJSTR.2021.35.005746
Highlights
The use of medicinal plants to treat diseases is a common practice among populations worldwide
About the toxicity in murine fibroblasts (L929), a reduction in cell viability (43% to 84%) was observed; in human keratinocytes (HaCat) there was a reduction in viability (32% to 72%)
This study is the first to perform a screening of potential biological activities of a hydroalcoholic extract of the bark of A. ambotay through of evaluating its antioxidant and antifungal activities, as well as toxic activities against strains of murine fibroblasts, human keratinocytes, human adenocarcinoma mammary gland/breast, murine tumor mammary gland, and Artemia salina
Summary
The use of medicinal plants to treat diseases is a common practice among populations worldwide. The Annonaceae family comprises 135 genera and 2,500 species Lúcio, et al [2], including Annona ambotay. This shrub is distributed throughout South America and is popularly known as envira-cajú or envirataia Maas, et al [3]. The members of this family provide edible fruits Vendramin, et al [4] and are used in perfumery, as well as in popular medicine for the treatment of diabetes Madaleno [5] and hypertension Battisti, et al [6]. This study is the first to perform a screening of potential biological activities of a hydroalcoholic extract of the bark of A. ambotay through of evaluating its antioxidant and antifungal activities, as well as toxic activities against strains of murine fibroblasts, human keratinocytes, human adenocarcinoma mammary gland/breast, murine tumor mammary gland, and Artemia salina
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