Assessment of Different Oxidative, Endocrinological and Biochemical Parameters using Catharanthus Roseus on Rats

Abdul Rashid Shaikh,Eshwa Dar,Kashif Iqbal,Muhammad Adnan,Muhammad Shahbaz Yousaf,Samar Akhtar

doi:10.9734/jpri/2021/v33i46a32871

Abstract

The current study was planned to assess the different oxidative, Endocrinological and biochemical parameters using extract of Catharanthus roseus (C. roseus) on diabetic rats. Three groups of Diabetic rats were assigned viz. Group A have Negative Control which was fed basal diet; Group B have Positive Control and was non-supplemented; and Group C supplemented with C. roseus extract. The results showed that blood glucose level, ALT, TGs and urea concentration was elevated non-significantly (P>0.05), of Group C which was supplemented by C. roseus when compared with non-supplemented Group B animals. In Group C which was supplemented by C. roseus, AST, and Cholesterol results were decreased as showed by statistics analysis (non-significantly). When level of Blood cortisol was compared between Group C and B, there was increased in Group C, as per non-significant statistics measurements (P>0.05). It was observed that level of T4 and T3 hormones was decreased in Group C (supplemented by herbal extract) when compared with Group B. When catalase enzyme results were checked in animals comprised of Group A, B and C, it showed that rate of catalase increased, respectively. In conclusion, Catharanthus roseus restore the levels of thyroid hormones, and cholesterol; and elevate catalase enzyme activity in animals which produce stress relieving effect.

Highlights

Diabetes Mellitus (DM) is a complex metabolic syndrome which occurs due to insufficient release of the insulin from the pancreatic beta cells defect in insulin action or both [1]
To the best of our knowledge, the only study reported for hypoglycemic effects of C. roseus in diabetic rats is by Palwasha et al 2015 in which only glucose level has been ascertained
The results show a non-significant statistical (P>0.05) lift in Alanine Transaminase (ALT), TGs, blood glucose levels of Group C which was supplemented by C. roseus when compared with Group B

Summary

Introduction

Diabetes Mellitus (DM) is a complex metabolic syndrome which occurs due to insufficient release of the insulin from the pancreatic beta cells defect in insulin action or both [1]. Diabetes can lead to some changes in biochemical parameters like cholesterol, urea and creatinine [4]. It is considered as one of the five causes of mortality worldwide [5] and has gained increasing attention as an emerging disease problem. The current estimates by World Health Organization reveal that near 2030, the number of diabetic patients will reach up to 370 million in the world. It would be one of the most common degenerative illnesses in human beings in future [6]

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Results

Conclusion