ASSESSMENT OF DIASTOLIC FUNCTION IN PATIENTS WITH DIABETIC NEUROPATHY

Abstract

"Diastolic dysfunction" is thought to be an indication of "diabetic cardiomyopathy" ", and "diabetic cardiovascular autonomic neuropathy" is linked to increased mortality risk. The goal of this study was to see how "diastolic dysfunction" and "cardiovascular autonomic neuropathy" are linked both of which were diagnosed in accordance with the guidelines. Methods: We assessed at seventy three participants Whose elective coronary angiography was referred, Diabetes mellitus was present in twenty-six of them, and twenty four of whom had impaired glucose tolerance, the other twenty-three people had normal "glucose tolerance". To identify "cardiovascular autonomic neuropathy", "autonomic function" tests were done, and "tissue Doppler imaging echocardiography" was employed to confirm "diastolic dysfunction". Results Autonomical cardiovascular neuropathy has been detected with diabetes type 2 diabetes in (28.8%) and with glucose-impaired tolerance in 6 (12.5%) patients. "Diastolic dysfunction" was found in 81 and 33 percent of patients with and without "cardiovascular autonomic neuropathy", respectively (P <0.001). "Early diastolic relaxation velocity" (Em) was considerably less in comparison to the group without cardiovascular autonomic neuropathy. ("5.4 0.9 vs. 7.3 2.1 cm⁄ s;P; P 0.001"), Moreover, the E⁄Em ratio was much higher. ("13.6 4.6 vs. 10.3 3.4 cm⁄ s;P, 0.001"). The significance of these data remained after controlling for "age, gender, coronary artery disease, hypertension, and HbA1c". In individuals with and without "cardiovascular autonomic neuropathy", significant "diastolic dysfunction" was found in 33 and 15% of patients, accordingly (P = 0.001).