Abstract
Background: Defaulting from Directly Observed Treatment Short Course (DOTS) is a big challenge to the effective control of TB. There are no published data on defaulting from DOTS in Benin City which necessitated this study to determine the rate of defaulting and identify factors that significantly contribute to defaulting in Benin City, Nigeria. Methods: This was a case control study from August to December 2011 of 1253 TB patients placed on DOTS in Benin City. The two DOTS centres used for the study were situated in University of Benin Teaching Hospital (UBTH) and Egor local government secretariat, both in Egor local government area (LGA) in Benin City. Out of 1253 patients registered on DOTS in the two study centres, 722 patients comprising of 172 defaulters and 550 non- defaulters were selected for the study using the inclusion and exclusion criteria. Logistic regression analysis was performed to determine association between independent variables and defaulting. Results: The default rate was 23.8%. Defaulting was significantly associated with: male sex (OR 3.05; 95%CI 1.60 - 5.80), being married (OR 3.06; 95%CI 1.34 - 6.99), a history of travel (OR 6.87; 95%CI 3.19 - 14.80) and concomitant drug use with TB drugs (OR 1.95; 95%CI 1.02 - 3.73). Conclusion: The default rate from DOTS in Benin City and the factors significantly associated with defaulting have given us some information initially unavailable about defaulting from DOTS in Benin City. TB control programmes taking these factors into consideration need to be done to promote compliance to treatment.
Highlights
Tuberculosis (TB) is a major public health problem globally
The factors independently associated with defaulting in the multivariate logistic regression analysis were male sex, high status occupation, being married, history of travel, use of TB drugs with other medications and occasional counseling by care provider (Table 3)
We found that patients who received occasional counseling about TB from service providers had a lower risk of defaulting compared to those who were counseled on each visit to the clinic, indicating that counseling has a negative implication on Directly Observed Treatment Short Course (DOTS) implementation in Nigeria
Summary
The prevalence, patterns of presentation and the mortality vary from one country to another and from one region of a country to another These variations depend on prevailing social factors such as socio-economic status of the people [1], HIV/AIDS, malnutrition [2] [3], crowded living conditions, level of development of health infrastructures, quality of available control programmes and the degree of drug resistance to anti-tuberculosis drugs [4]. There are no published data on defaulting from DOTS in Benin City which necessitated this study to determine the rate of defaulting and identify factors that significantly contribute to defaulting in Benin City, Nigeria. TB control programmes taking these factors into consideration need to be done to promote compliance to treatment
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
