Abstract
Aim: This study was aimed to evaluate the association between serumD-dimer, serum Ferritin with disease severity in patents havingCOVID-19. Methods:Total 80 confirmed COVID-19 patients were enrolled in this cross sectional study. Samples were assessed by positive SARSCoV- 2 by RT-PCR testing and were collected from two tertiary Hospitals(IbnSina Medical College Hospital and Ibrahim Cardiac Hospital and Research Institute).We also performed CT findings of COVID patients with or without pulmonary involvement. COVIDpositive patients were divided into two groups (Group 1 and Group2) according to lungs involvement confirmed by CT-scan. In this analysis, several variables such as gender, age, D-dimer and serum ferritin were taken. Results: The Mean of D-dimer in Group-1 subjects was 4.26±3.60mg/L and in Group-2, this was 0.59±1.08mg/L. So D-dimer level was significantly raised in COVIDpneumonic patient (P value = <0.001). The mean of ferritin(554.65±515.841)ng/ml for pneumonic patient was also highly significant than the mean(133.70±109.22)ng/ml of COVID without pneumonia. Conclusion:D-dimer and S. ferritin were elevated in patients with COVID-19. These two reliable biomarkers are correlate with the disease severity and useful for better management of COVIDpositive patients. Bangladesh Journal of Medical Science Vol.20(5) 2021 p.166-170
Highlights
For the last one and half year the entire World is experiencing the emergence and devastation caused by COVID-19.The clinical picture of patients with COVID-19 has a pattern of respiratory dominance and depends on the tropism of the virus towards the target organs of the body, because COVID-19 virus uses the ACE-2 receptor for its entry into the host cell
We found that an elevated D-dimer was associated with an increased composite poor outcome, especially mortality and severe COVID-19
This finding supports the hypothesis that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection could induce the dysfunction of the hemostatic system, leading to a hypercoagulable state, a condition which we commonly encounter in sepsis[7,8].Recent evidence of lung pathology dissection has shown occlusion and micro-thrombosis formation in pulmonary small vessels of patients critically ill with COVID-199
Summary
For the last one and half year the entire World is experiencing the emergence and devastation caused by COVID-19.The clinical picture of patients with COVID-19 has a pattern of respiratory dominance and depends on the tropism of the virus towards the target organs of the body, because COVID-19 virus uses the ACE-2 receptor for its entry into the host cell. The virus binds ACE-2 with an affinity 1020 times greater than SARS-CoV. This receptor is highly expressed in multiple body tissues, including lung, gastrointestinal, kidney and cardiac tissue, explaining the symptoms present in the prodrome of the disease[1]. In mild COVID, lung is not involved whereas in severe COVIDpatient develops ARDS. It is universally acknowledged that severe COVID-19 cases have higher mortality than mild cases because severe cases are more likely to suffer ARDS, septic shock, or metabolic acidosis[2]. It is necessary to distinguish between severe and mild patients at an early stage. According to a report by Yong Gao[3], D-dimer can be measured to estimate the severity of COVID-19 and help to diagnose severe COVID-19 patients earlier
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