Abstract
Background: The most virulent of the human malaria parasites is P. falciparum which is responsible for the bulk of the malaria-related morbidity and mortality. Changes in blood cell parameters are already a well-known feature of malarial infections
 Aim: The purpose of this research was to assess the total blood count and D-dimer levels in patients with P. falciparum malaria in Khartoum State, Sudan.
 Study Design: It is case- control study was conducted on blood cells prameters and plasma D-dimer for patients infected with Plasmdium falciparum malaria
 Place and Duration of Study: study was carried out in Yastabshiroon hospital, Khartoum state, from October 2020 to January 2021.
 Methodology: The study comprised fifty people who tested positive for P. falciparum using the National Public Health Laboratory's malaria diagnostic standard. The control group consisted of fifty healthy Khartoum locals with about equal gender and age distribution. To collect data from the study group's personal and medical information, such as name, gender, age, and medical condition, a structured questionnaire was developed.
 Result: D-dimer levels were considerably greater in P. falciparum malaria cases compared to non-falciparum malaria cases, neutrophil and lymphocyte counts were significantly lower, although white blood cells (WBCs) count was significantly lower in P. falciparum infection patients compared to non-falciparum (p≤0.05). Hemoglobin concentration and platelet count were similarly significantly lower (p≤0.05). Platelet counts and mean cell hemoglobin concentration (MCHC), on the other hand, were significantly lower in individuals with severe parasitemia compared to those with low and moderate parasitemia.
 Conclusion: The study concluded that P. falciparum infection causes considerable hematological alterations. The results of the current investigation revealed a significant increase in the D-dimer mean level, as well as a significant decrease in the count of hemoglobin, total white blood cells (TWBCs), lymphocytes, neutrophils, and platelets. It was also discovered that patients with high parasitemia had considerably lower platelet counts and mean cell hemoglobin concentration (MCHC) levels than those with low and moderate parasitemia.
Highlights
Malaria remains an important source of morbidity and death in more than 90 countries, responsible for at least one million deaths and 241 million illness episodes each year [1]
The remaining parameters, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), mean platelet volume (MPV), red cell distribution width - coefficient of variation (RDW-CV) and red cell distribution width -standard deviation (RDWSD),and differential percentages lymphocyte %, mixed %, and neutrophil %, are calculated or derived
The current investigation discovered a significant increase in the mean of D-Dimer (2.27 ±1.7) for patients compared to controls (0.47± 0.1), (p=0.000), and a significant decrease in the mean of total white blood cells (TWBCs) (5.05 ±1.7) for cases compared to controls (6.75 1.8), (p=0.000)
Summary
Malaria remains an important source of morbidity and death in more than 90 countries, responsible for at least one million deaths and 241 million illness episodes each year [1]. P. falciparum is responsible for 91 % of malaria cases worldwide, with the majority (86%) occurring in Africa [2]. Malaria is a major public health issue in Sudan, accounting for 37% of all maternal death [4]. The most virulent of the human malaria parasites is P. falciparum which is responsible for the bulk of the malaria-related morbidity and mortality. Changes in blood cell parameters are already a well-known feature of malarial infections Aim: The purpose of this research was to assess the total blood count and D-dimer levels in patients with P. falciparum malaria in Khartoum State, Sudan. Study Design: It is case- control study was conducted on blood cells prameters and plasma Ddimer for patients infected with Plasmdium falciparum malaria Place and Duration of Study: study was carried out in Yastabshiroon hospital, Khartoum state, from October 2020 to January 2021. To collect data from the study group's personal and medical information, such as name, gender, age, and medical condition, a structured questionnaire was developed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
