Abstract
The aimof the study was to assess the relationship between the detection of hyperechogenic deposits (HD) in the hyaline cartilage of the knee joints (KJ) at ultrasonography in patients with osteoarthritis (OA), clinical manifestations and structural changes according to KJ ultrasonography and radiography.Material and methods.A prospective analysis of clinical, radiological and ultrasonographic data of 114 patients with knee OA was conducted. The patients were divided into two groups: 32 patients with HD detected in at least one of the KJ, and 82 patients without HD; 32 patients of the 1st group and 34 patients of the 2nd group were observed for 2 years. A comparative assessment of initial clinical manifestations (WOMAC index), x-ray data and ultrasonographic parameters of the subchondral bone, hyaline cartilage and the degree of synovial inflammation in the groups of patients at the beginning of the study and after 2 years was carried out. The exclusion criteria were other joint diseases; paroxysmal course of the inflammatory process in KJ; trauma and history of operations on KJ; ESR >20 mm/h, uric acid level >360 μmol/l and C-reactive protein >5 mg/l.Results and discussion.HD in hyaline cartilage was found in 28.1% of patients with knee OA. After 2 years HD remained in all patients having them at inclusion, and in 5.6% of the patients they were found for the first time. In 13 patients with HD in hyaline cartilage, synovial fluid was studied and in all cases calcium pyrophosphate crystals were identified by phase-contrast microscopy. The presence of HD in the hyaline cartilage of patients with knee OA was accompanied by more pronounced ultrasonographic signs of synovitis and was associated with a higher rate of osteophytes growth in the absence of the changes of the hyaline cartilage thickness according to the ultrasonography and the width of the joint space according to x-ray.Conclusion.The presence of HD in the hyaline cartilage of patients with knee OA according to ultrasound examination may be associated with the deposition of calcium pyrophosphate crystals and is associated with persistent synovitis and accelerated growth of osteophytes.
Highlights
The aim of the study was to assess the relationship between the detection of hyperechogenic deposits (HD) in the hyaline cartilage of the knee joints (KJ) at ultrasonography in patients with osteoarthritis (OA), clinical manifestations and structural changes according to KJ ultrasonography and radiography
The patients were divided into two groups: 32 patients with HD detected in at least one of the KJ, and 82 patients without HD; 32 patients of the 1st group and 34 patients of the 2nd group were observed for 2 years
The presence of HD in the hyaline cartilage of patients with knee OA was accompanied by more pronounced ultrasonographic signs of synovitis and was associated with a higher rate of osteophytes growth in the absence of the changes of the hyaline cartilage thickness according to the ultrasonography and the width of the joint space according to x-ray
Summary
Цель исследования – оценка взаимосвязи между выявлением в гиалиновом хряще коленных суставов (КС) гиперэхогенных депозитов (ГД) при ультрасонографии у больных остеоартритом (ОА) КС, клиническими проявлениями и структурными изменениями по данным ультрасонографии и рентгенографии КС. У 13 больных с ГД в гиалиновом хряще исследовалась синовиальная жидкость и во всех случаях были идентифицированы кристаллы пирофосфата кальция при фазово-контрастной микроскопии. Наличие ГД в гиалиновом хряще больных ОА КС по данным ультразвукового исследования может быть связано с депонированием кристаллов пирофосфата кальция и ассоциируется со стойким синовитом и ускорением роста остеофитов. Оценка клинической значимости выявления гиперэхогенных депозитов в гиалиновом хряще при ультрасонографии у больных остеоартритом коленных суставов. Цель исследования – оценка взаимосвязи между выявлением при УЗИ ГД в гиалиновом хряще больных ОА коленных суставов (КС), клиническими проявлениями и структурными изменениями по данным УЗИ и рентгенографии КС. При наличии возможности выполнялась диагностическая пункция КС и проводилась фазово-контрастная микроскопия СЖ с применением микроскопа Аmscope T610PH-3 40X-1000X 3MP
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
