Assessment of CIP2A and ROCK-I expression and their prognostic value in breast cancer.

Abstract

Breast cancer is themost leading cause ofcancer death in females worldwide. Identification ofnovel biomarkers for prognosis is required. Imunohistochemical evaluation ofCIP2A and ROCK-1 expressions in 126 breast tissue specimens stratified as 21 ductal hyperplasias, 17 duct carcinoma in situ (DCIS) and 88 invasive carcinomas (56 invasive ductal carcinomas NST, 32 invasive lobular carcinomas) was studied. High CIP2A expression was detected in 48.9% ofinvasive carcinomas. CIP2A overexpression was significantly related to Nottingham prognostic index (NPI) (p=0.011), stage (p=0.01), ER negativity (p=0.031), PR negativity (p=0.048), and HER-2 positivity (p=0.02). CIP2A was significantly overexpressed in triple-negative breast cancer (TNBC) (p=0.004). ROCK-1 expression was detected in 54.5% ofinvasive carcinomas. Statistically significant associations were observed between ROCK-1 expression and NPI (p=0.032), stage (p=0.002), ER negativity (p=0.012), PR negativity (p=0.023), HER-2 positivity (p=0.016), and TNBC subtype (p=0.033). Apositive association between CIP2A and ROCK-1 expressions (p<0.0001) was documented. There was asignificant association between shorter overall survival and high CIP2A and positive ROCK-1 expressions (p<0.0001) and (p<0.0001). CIP2A and ROCK-1 expressions could be used as markers for thepoor prognosis ofbreast cancer.