Assessment of Changes in Concentration of Total Antioxidant Status, Acute-Phase Protein, and Prolactin in Patients with Osteoarthritis Subjected to a Complex Spa Treatment with Radon Water: Preliminary Results.

Jadwiga Kuciel-Lewandowska,Lilla Pawlik-Sobecka,Małgorzata Paprocka-Borowicz,Jan Gnus,Michał Kasperczak

doi:10.1155/2020/9459418

Jadwiga Kuciel-Lewandowska, Lilla Pawlik-Sobecka + Show 3 more

Open Access

https://doi.org/10.1155/2020/9459418

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Journal: PPAR research	Publication Date: Apr 23, 2020
Citations: 1	License type: CC BY 4.0

Affiliation: University of Wrocław

Abstract

Spa treatment brings many clinical benefits such as improved physical activity, pain relief, and improved quality of life. In the literature, there are only few objective studies evaluating changes in metabolism possibly influencing clinical outcomes. The main purpose of our study was the assessment of the effect of spa treatment on changes in concentration of TAS, CRP, and PRL in patients with osteoarthritis. Patients receiving spa treatment were enrolled. TAS, CRP, and PRL levels were obtained using standard tests before the beginning of treatment as well as on days 5 and 18. The study group consisted of n = 35 patients with peripheral joint and spinal osteoarthritis. The control group consisted of 15 people selected from the resort staff, who also suffered from osteoarthritis and had no contact with radon. An increase in TAS concentration was found in the study group following therapy while the control group was characterized by a significant decrease in TAS. On day 5, an increase in TAS concentration was found in both groups, however, with much worse result in the control group. No changes in CRP concentration were statistically significant. PRL concentration was proven to decrease in a statistically significant way after treatment in the study group. This trial is registered with NCT03274128.

Highlights

Spa treatment brings many positive clinical benefits such as improved physical activity, pain relief, and improved quality of life
In living organisms oxygen reacting with organic compounds leads to their oxidation accompanied by partial reduction of oxygen itself due to various external and internal factors, and as a consequence reactive, oxygen species (ROS)
An increase in the TAS level was observed in tests II and III

Summary

Introduction

Spa treatment brings many positive clinical benefits such as improved physical activity, pain relief, and improved quality of life. There are only few objective studies evaluating changes in metabolism possibly influencing clinical outcomes. Due to much controversy regarding spa treatment, we have attempted to prove the effect of such a therapy on selected metabolic parameters. In living organisms oxygen reacting with organic compounds leads to their oxidation accompanied by partial reduction of oxygen itself due to various external and internal factors, and as a consequence reactive, oxygen species (ROS)

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