Abstract
In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examined 118 patients who were diagnosed with typical RP. Visual acuity (VA), visual field using a Humphrey Field Analyzer with the central 10-2 SITA-Standard program, and optical coherence tomography measurements were obtained. The slopes, which were derived from serial values of mean deviation (MD), macular sensitivity (MS), or foveal sensitivity (FS) obtained for each eye by a linear mixed model, were used for analysis. MS and FS were calculated as the average retinal sensitivity of 12 and 4 central points respectively. There were statistically significant interactions of times with levels of the central subfield thickness (CST) on the slopes of MS and FS. Compared to the eyes without macular complications, the eyes with macular complications had steeper MD, MS and FS slopes, and this interaction was no significant, but marginal trend for the MS or FS slope (P = 0.10, 0.05, respectively). The central retinal sensitivity (i.e., MS and FS) slopes calculated were effective indices of the progression of central visual function in RP.
Highlights
In the present study, we focused on central visual function, which involves primarily cone photoreceptor cells[5]
We defined the progression rate of visual field loss and elucidated the factors that contribute to this progression rate in patients with retinitis pigmentosa (RP), using automated static perimetry
This is the first study to define the progression of central visual function based on the long-term follow-up data in over 100 RP patients
Summary
We focused on central visual function, which involves primarily cone photoreceptor cells[5]. There have been no studies assessing longitudinal central visual function and its related factors. RP is a chronic progressive disease, and it is important to be able to measure the slight changes of central visual function[9], which could be affected by macular complications. Goldmann visual field testing has been used as a general and standard perimetry method for patients with RP10–12, but it is difficult to quantify the central progression of RP as represented by numerical values. Birch et al showed that dark-adapted visual fields were obtained on a modified OctopusTM 201 automated perimeter. They studied the relationships between the rod visual field area using dark-adapted visual fields and the parameters derived from full-field rod ERG13. We investigated the associations among several factors related to RP disease progression
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