Abstract
Background: Breast cancer is the most prevalent cancer and one of the most common mortality causes among females worldwide. Accordingly, it is a main concern of scientists and doctors. Evolving serum tumor markers helping to early diagnosis of the breast cancer and estimating important prognostic factors is then mandatory. Among them are the cancer antigen 15-3 (CA15-3) as well as the carcinoembryonic antigen (CEA). Some researchers concluded their prognostic importance while others not. Aim of the study: This research was aimed at assessing the prognostic function of CA 15-3 and CEA in the Egyptian females. Patients and methods: Research participants are 120 BC patients and 30-year-old and BMI corresponding safety checks; the rates of CEA serum and CA 15-3 were studied and associated with the clinicopathological features of BC patients. Results: Our study showed that both markers differed significantly between healthy controls and patients with BC, and gradually increased with severity of the disease. Conclusion: our findings suggest that the levels of serum CA 15-3 and CEA and are intimately related to the prognosis of breast cancer, as they revealed a gradual increase with the severity of the disease, supporting their role as biomarkers of prognosis.
Highlights
Breast cancer arises due to an association with an environmental cause and a genetically vulnerable host [1]
This study aimed to assess the importance of the cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) levels in the breast cancer diagnosis and prognosis in Egyptian females
Previous study showed that serum levels of CA15-3 and CEA were significantly the prognostic factors of tumor progression as the size of the tumor and the status of lymph nodes affection [06], slightly increased serum levels of CA15-3 and CEA were shown in the stage III breast cancer [17]
Summary
Breast cancer arises due to an association with an environmental (external) cause and a genetically vulnerable host [1]. A tumor marker is a substance that is secreted by normal cells and cancer cells as well It shows much higher levels in case of cancer activity. Some studies reported the utility of measuring serum CA 15-3 levels as a screening method for breast cancer among other malignant tumors. The utility of CA15-3 and CEA as biomarkers aiding in the diagnosis of recurrence cases in breast cancer is proposed It was found by Darlix et al that the CA 15-3 in metastatic breast cancer patients is independent prognostic factor [8]. Conclusion: our findings suggest that the levels of serum CA 15-3 and CEA were closley related to the prognosis of breast cancer, that showing a gradual increase with the severity of the disease, supporting their role as biomarkers of prognosis
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