Abstract
Diabetes mellitus is a major public health problem; it is synchronized with the development of many complications of which cardiovascular disease is the most prevalent and detrimental. This study aimed at comparing the strength of various cardiovascular risk indices among diabetes type 2 patients. The risk indices evaluated were: Apoprotein A1, Apoprotein B1, lipoprotein (a), total cholesterol, (TCHOL), Triglyceride (TG), low density lipoprotein (HDL), TC/HDL, pentad and tetrad. Two hundred and four (204) subjects were studied comprising of 152 diabetes subjects and 52 non-diabetics as control. The result shows significantly higher values in the mean blood pressure of diabetic subjects when compared with the control at (p < 0.05. Mean HbA1C and total cholesterol values for diabetes subjects were significantly higher when compared with the control. However, the HDL-cholesterol of the diabetes subjects was significantly lower when compared to the control subjects. There was no significant difference in triglyceride level of both groups. The mean values of Apo A, Apo B and lipoprotein a, were higher in diabetic subjects compared to the control subjects at (p < 0.05). Comparison of the liporprotein induces in terms of sensitivity, specificity and accuracy, Lpa had a sensitivity of 97.3%, specificity of 100% and accuracy of 95.7%, next was pentad with sensitivity of 91.45%, specificity of 100% and accuracy of 95.73%. Tetrad had a sensitivity of 81.05%, specificity of 100% and accuracy of 90.5%, the TC/HDL ratio and the least accuracy of 75.76%. Based on the overall accuracy Lpa tend to display highest accuracy followed by PENTAD and TETARD.
Highlights
Diabetes Type 2 goes on undiagnosed for many years; it is most predominant type of diabetes since it represents 90% of diabetes cases
The clustering of vascular risk seen in association with insulin resistance (IR), often referred to as the metabolic syndrome, has led to the view that cardiovascular risk appears early, prior to the development of Type 2, whilst the strong relationship between hyperglycaemia and microvascular disease indicates that this risk is not apparent until ‘frank’ hyperglycaemia appears [2]
This study focused on comparing the strength of various cardiovascular risk indices on diabetes type 2 patients
Summary
Diabetes Type 2 goes on undiagnosed for many years; it is most predominant type of diabetes since it represents 90% of diabetes cases. The clustering of vascular risk seen in association with insulin resistance (IR), often referred to as the metabolic syndrome, has led to the view that cardiovascular risk appears early, prior to the development of Type 2, whilst the strong relationship between hyperglycaemia and microvascular disease (retinopathy, nephropathy, neuropathy) indicates that this risk is not apparent until ‘frank’ hyperglycaemia appears [2]. These concepts highlight the progressive nature of both Type 2 and associated cardiovascular risk, which pose specific challenges at different stages of the life of an individual with diabetes mellitus (DM). Awareness of specific issues associated with gender and race and, the effects of DM in women including epigenetic and influences on non-
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Clinical and Experimental Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
