Assessment of cardio-vascular disease risk in diabetic population of Northern India

Abstract

: Type 2 Diabetes mellitus (DM) is a chronic metabolic disorder. India has 72.9 million people living with diabetes (8.8%). The Cardio Vascular Disease (CVD) risk increases in patients with Type 2 diabetes. The Non-HDL-C level includes cholesterol carried in several atherogenic lipoproteins. The estimation of non-HDL-C may provide a better means to follow these patients toward their treatment goals. The study compares the level of non-HDL-C in non diabetic, pre-diabetic and diabetes patients and their occurrence of dyslipidemia. : The study group included 1418 patients and were grouped as – Non diabetic, pre-diabetic and Diabetic, having age group of 20 to 85 years. The Male:Female ratio was 1.9:1. Their blood samples were analysed in Clinical Biochemistry Laboratory on automated chemistry analyzer with quality checks.: The Non Diabetic group (HbA1c<5.7%) had 564 patients having Non-HDL-C 127.85±1.79 mg/dl; the Pre-Diabetic group (HbA1c-5.7-6.4%) had 316 patients with Non-HDL-C 132.37±2.35 mg/dl and Diabetic group (HbA1c >6.4%) had 538 patients and its non HDL-C was 148±4.27 mg/dl. : This study showed the groups, pre-diabetic and diabetic, had Non-HDL-C >130mg/dl. An increase in Non-HDL-C levels is associated with increased risk of CVD according to Adult Treatment Panel (ATP) III guidelines.