Abstract
The mucolytic drug bromhexine hydrochloride (BH), was formulated in different ohthalmic dosage forms. The influence of the drug from the different formulations on tear flow rate in humans was investigated. The formulations tested were: BH aqueous solution, methylcellulose and carbopol 934 hydrogels; and two polymeric inserts, namely; Gantrez AN 169 (G) and cellulose acetate (CA). The greatest influence on tear production was found using carbopol 934. Although both polymeric inserts showed less influence than carbopol 934, they sustained the action of BH in the human eye.
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