Abstract
Confocal laser scanning microscopy (CLSM) is a type of high-resolution and comparatively non-destructive fluorescence imaging technique that overcomes the limitations of conventional wide-field microscopy and facilitates the generation of high-resolution 3D images from relatively thick sections of tissue. In addition, CLSM enables the in situ characterization of tissue microstructure. Images generated by CLSM have been utilized for the study of articular cartilage, bone, muscle, tendon and ligament, and in the field of orthopaedics. More importantly, recent evolution in techniques and technologies have facilitated a relatively widespread adoption of this imaging modality, with increased “user friendliness” and flexibility; therefore, applications of CLSM exist in the rapidly advancing field of orthopaedic implants and the investigation of joint lubrication. Accordingly, this chapter focuses on the specific applications, as well as the recent and future direction of developments of CLSM in orthopaedic research in tissues of orthopaedic interest.
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