Abstract
Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF). To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally. This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas. Children were followed up for an average of 5.7 years (6 008 985 total person-years of exposure). Data analysis was conducted from April 1 to August 31, 2020. Conception by IVF for state residents who gave birth to liveborn singletons during the study period. Birth defect diagnoses recorded by statewide registries. Cancer diagnosis as recorded by state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs for birth defect-cancer associations separately in fertile and IVF groups. A total of 1 000 639 children (51.3% boys; 69.7% White; and 38.3% born between 2009-2012) were in the fertile group and 52 776 were in the IVF group (51.3% boys; 81.3% White; and 39.6% born between 2009-2012). Compared with children without birth defects, cancer risks were higher among children with a major birth defect in the fertile group (hazard ratio [HR], 3.15; 95% CI, 2.40-4.14) and IVF group (HR, 6.90; 95% CI, 3.73-12.74). The HR of cancer among children with a major nonchromosomal defect was 2.07 (95% CI, 1.47-2.91) among children in the fertile group and 4.04 (95% CI, 1.86-8.77) among children in the IVF group. The HR of cancer among children with a chromosomal defect was 15.45 (95% CI, 10.00-23.86) in the fertile group and 38.91 (95% CI, 15.56-97.33) in the IVF group. This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally.
Highlights
Births conceived with in vitro fertilization (IVF), the ex vivo manipulation of both sexes’ gametes to achieve conception, accounted for 2% of all US births in 2017.1,2 Children born from IVF have been shown to be at greater risk for birth defects[3] and for childhood cancer[4,5] compared with children conceived their naturally
Compared with children without birth defects, cancer risks were higher among children with a major birth defect in the fertile group and IVF group (HR, 6.90; 95% CI, 3.73-12.74)
This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally
Summary
Births conceived with in vitro fertilization (IVF), the ex vivo manipulation of both sexes’ gametes to achieve conception, accounted for 2% of all US births in 2017.1,2 Children born from IVF have been shown to be at greater risk for birth defects[3] and for childhood cancer[4,5] compared with children conceived their naturally. In this study we present the results of a population-based linkage of IVF births, birth defects, and childhood cancer in 4 US states to estimate the risk of cancer among children with birth defects conceived through IVF vs those conceived naturally
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