Abstract
Aim. Assessment of biological age and the rate of aging of patients with undifferentiated connective tissue dysplasia. Materials and methods. 89 women with 6 or more undifferentiated connective tissue dysplasia phenes and 42 women of the control group with less than 6 undifferentiated connective tissue dysplasia phenes had their biological age determined using the method of V.P. Voitenko. — Tokar A.V. — Chebotarev D.F. (year 1984). External phenotypic signs of undifferentiated connective tissue dysplasia were evaluated during general examination, anthropometry, heart and abdominal organs ultrasonography using «Hitachi F37» device. After calculating biological age, expected biological age was determined using the following formula: eBA = 0,581хCA+17,24 where CA is calendar age. Then the aging rate coefficient was defined (ARC = BA/eBA), which illustrates the number of times the biological age of the examinee is greater or less than expected biological age of her peers. Results. Patients of the main group had a gap (about 8 years) between calendar age and biological age, a positive difference between biological age and expected biological age, as well as aging rate coefficient > 1. Conclusions. Women with undifferentiated connective tissue dysplasia have accelerated aging mechanisms.
Highlights
External phenotypic signs of undifferentiated connective tissue dysplasia were evaluated during general examination, anthropometry, heart and abdominal organs ultrasonography using «Hitachi F37» device
The aging rate coefficient was defined (ARC = BA/eBA), which illustrates the number of times the biological age of the examinee is greater or less than expected biological age of her peers
National recommendations of the Russian Scientific Medical Society of Therapists for diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia
Summary
1 — Акционерное Общество санаторий «Металлург», Ижевск, Россия 2 — ФГБОУ ВО «Ижевская Государственная Медицинская Академия Минздрава РФ», Ижевск, Россия. Оценка биологического возраста и темпа старения у пациенток с недифференцированной дисплазией соединительной ткани. Определяли должный биологический возраст по формуле: дБВ = 0,581хКВ+17,24, где КВ — календарный возраст. На основе коэффициента скорости старения (КСС = БВ/должный БВ), определяли, во сколько раз биологический возраста обследуемой больше или меньше, чем должный биологический возраст ее сверстниц. У пациенток основной группы выявлен разрыв (около 8 лет) между календарным и биологическим возрастом, положительная разница между биологическим возрастом и должным биологическим возрастом, а также коэффициент скорости старения >1. У пациенток с недифференцированной дисплазией соединительной ткани происходит ускорение течения механизмов старения. Ключевые слова: биологический возраст, преждевременное старение, недифференцированная дисплазия соединительной ткани Для цитирования: Кононова Н.Ю., Чернышова Т.Е., Загртдинова Р.М. ОЦЕНКА БИОЛОГИЧЕСКОГО ВОЗРАСТА И ТЕМПА СТАРЕНИЯ У ПА-.
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