Assessment of autonomic dysfunction between type I and type II diabetes mellitus

Abstract

Introduction: The diabetes is the most common disease in the present world and India is country with highest incidence of Diabetes Mellitus in the world. The autonomic nervous dysfunction due to diabetes is the common complication of the diabetes. In this study autonomic dysfunction in pateints with type I and type 2 DM and its correlation with the duration of diseases is studied. Materials and Methods: The study was conducted on 30 type I diabetic patients and 40 type II diabetic pateints. All the diabetic patients were questioned about the presence of symptoms reported to be related to autonomic neuropathy. The conventional autonomic function tests were performed on all the subjects inclusive of sympathetic and parasympathetic tests. The scoring of positive and negative for autonmomic dysfuntion was done. Results: The duration of disease in type 1 diabetes, was 6 to 15 years and in type 2 diabetes it was 8 to 18 years with mean duration of 8.5 and 14 years respectively. The mean HbA1C in type 1 DM was 6.21±2.09 and it was 7.50±2.45 in type 2 DM. Comparison of autonomic function tests in the form of heart rate and BP response in subjects with type 1 and type 2 showed that there no significant statistical difference between the groups. Conclusion: It can be concluded the presence of autonomic dysfunction in type 1 and type 2 diabetes mellitus might be due to nerve damage. The duration of diabetes is directly related to such autonomic dysfunction. Keywords: Diabetes Mellitus type 1, Diabetes Mellitus type 2, Autonomic Functions Tests.