Assessment of asprosin level and some of physiological variables in patients with cardiovascular diseases in Kirkuk city, Iraq

Abstract

Introduction and Aim: Asprosin is a novel fasting-induced glucogenic adipokine, which stimulates the liver to release glucose into the blood stream. The aim of this study was to examine the role of asprosin as well as various physiological and oxidative stress factors in atherosclerosis and myocardial infarction patients in comparison to healthy controls in Kirkuk city, in order to clarify whether asprosin helps in protecting heart and preventing heart disease. Materials and Methods: This study included blood samples collected from patients (n=70) and normal healthy controls (n=20), aged between 45-65 years from the Kirkuk General Hospital and external specialized clinical between December 2021 to February 2022. The samples were divided into three groups which included healthy controls (n=20), patients suffering from atherosclerosis (n=40) and myocardial infarction (n=30) respectively. Individuals in all groups were tested for their blood ASP, CPK-BM Tnt and lipid profile levels. Blood serum was also tested for concentration of FBS, INS, HbA1c, MDA and GSH. Results: The asprosin, CPK-BM, Cardiac troponin (TNt) and INS levels was observed to be significantly elevated in atherosclerosis patients in comparison to healthy controls. However, in myocardial infarction patients significant increase levels was seen only for CPK-BM and INS levels. Lipid profiling showed that except for HDL levels, significant increased levels for TC, TG, LDL and VLDL in both atherosclerosis and MI patients as compared to healthy individuals. The concentration of FBS was seen elevated in blood serum of atherosclerosis and MI patients in comparison to controls. No significant increase was observed for HbA1c and oxidative stress hormones MDA and GSH). Conclusion: Changes in asprosin levels in patients with cardiovascular disease could be considered as a biochemical marker to estimate the severity of injury in heart and heart muscles.